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Carcinogenesis In the life span carcinogenicity analyze carried out in B6C3F1 mice, methylphenidate induced an increase in hepatocellular adenomas, As well as in males only, a rise in hepatoblastomas at a daily dose of close to 60 mg/kg/working day. This dose is somewhere around 2 instances the MRHD of 60 mg/working day supplied to little ones on m